Drug Information Center News letter

Adigrat University, Collage of Health Science, Department of Pharmacy

Selamawit Mengstu

April,8;2019

Inside this issue:	Phage
Liver, colon cancer cells thwarted by compounds derived from hops	1
joke	1
Antimalarial drug can cause retinopathy	2
6 Famous Musicians / Who Have Battled Drug Addiction and Alcoholism	2
Thing all us should know	2
5 FDA-Approved Prescription Drugs Later Pulled from the Market	2
Entertainment	2

Liver, colon cancer cells thwarted by compounds derived from hops

The plant that adds flavor, color and bitterness to beer also produces a primary compound that thwarts cancer cells, and two important derivatives of the compound do as well, new research at Oregon State University shows. Unlike the primary compound, xanthohumol, known as XN, the derivatives don't metabolize into phytoestrogens. Phytoestrogens are plant-based chemicals similar to female sex hormones that help some types of tumors grow and can cause other health problems as well.

Xanthohumol is produced by humulus lupulus, the common hop plant. More than 20 years ago, researchers discovered that XN inhibits cell growth in a variety of cancer cell lines.
"But a potential problem with XN is that enzymes in the liver and the gut microbiota metabolize it into 8- prenylnaringenin, or 8-PN, the most potent phytoestrogen known,"
The derivatives that don't metabolize into 8-PN are DXN, short for dihydroxanthohumol, and TXN, which refers to tetrahydroxanthohumol.

A man goes into a drugstore and asks the pharmacist if he can give him something for the hiccups. The pharmacist promptly reaches out and slaps the man’s face. “What did you do that for?” the man asks. “Well, you don’t have the hiccups anymore, do you?” The man says, “No, but my wife out in the car still does!”

Colorectal cancer is the third most common cause of cancer-related death in the United States, and liver cancer ranks fifth. The incidence of liver cancer, though, has tripled in the last four decades.
"For both of those cancers, discovering new compounds for prevention and treatment is imperative,"

REFERENCE
Isabelle E Logan, Cristobal L Miranda, Malcolm B Lowry, Claudia S Maier, Jan F Stevens, Adrian F Gombart. Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines. , 20(5), 1203. doi: 10.3390/ijms20051203.

Drug Information Center News Letter

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Antimalarial drug can cause retinopathy
Antimalarial drugs are largely used for the treatment of various systemic diseases. They can cause toxic retinopathy, which can lead to blindness.We report the case of a 32-year-old male with a systemic lupus erythematosus treated with hydroxychloroquine 400mg per day and then chloroquine 300mg per day during 8 and 9years respectively. Eighteen months after his latest visual examination, the patient experienced bilateral vision loss. Fundus examination revealed a bull's eye maculopathy. Additional tests including multifocal electroretinogram showed severe bilateral functional impairment in the parafoveal area leading to diagnosis of severe toxic retinopathy induced by antimalarial drugs.In 2016, the American Academy of Ophthalmology revised the previous 2011 recommendations concerning early retinal toxicity screening strategy which should be first based on both automated 10-2 visual fields and spectral-domain optical coherence tomography (SD OCT).
Reference
Guiot A, Couturine M,Tebib JG,Abouaf L Journal Article, English Abstract (lang: fre) DOI: 10.1016/j.revmed.2018.02.013

6 Famous Musicians Who Have Battled Drug Addiction and Alcoholism
Ozzy Osbourne 6. Amy Winehouse
Anthony Kiedis
Kurt Cobain
Britney Spears
Snoop Dogg

Top 3 prediction of how world end
Threat one: Solar storms
Threat two: Cosmic collisions
Threat three: Super volcanoes

5 FDA-Approved Prescription Drugs Later Pulled from the Market
Accutane(Isotretinoin)-Use:Acne
Manufacturer: Hoffman-La Roche
On market for 27 years 1982– June 2009.
Baycol (Cerivastatin)-Use: Cholesterol reduction Manufacturer: Bayer A.G.
On market for 3 years 1998– Aug. 2001.
Bextra (Valdecoxib)- Use: NSAID (pain relief) Manufacturer: G.D. Searle & Co.
On market for 3.3 years Nov.20, 2001-
Apr.7,2005.
Cylert (Pemoline)- Use: Central nervous system stimulant to treat ADHD/ADD Manufacturer: Abbott Laboratories
On market for 30 years 1975– Oct. 2010.
Darvon & Darvocet (Propoxyphene)-Use: Opioid pain reliever Manufacturer: Xanodyne
On market for 55 years 1955– Nov.19,
2010.
Reference
FDA, "FDA: Pfizer Voluntarily Withdraws Cancer Treatment Mylotarg from U.S. Market," www.fda.gov, June 21, 2010

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Adigrat university of pharmacy was launched before 5 years. From Adigrat university department of pharmacy we are the first batch and the senior one. The department is working greatly on:
pharmacy association to get pharmacy department on the better place for the coming pharmacy students or the next generation pharmacists.
To have its own bank account.
To make pharmacy known and respected profession by the society.
To solve health problems in the society.
To solve problems in the pharmacy department.

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